Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required): eligibility, deadline, and how to apply (2026)

The Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required) is a federal funding opportunity administered by the National Institutes of Health. This guide covers everything you need to know to determine whether you qualify and how to submit a competitive application once the next cycle opens.

Use our free Grant Finder to discover additional programs you may be eligible for based on your organization type and location.

Eligibility requirements

To qualify for the Clinical Coordinating Center for NCCIH Multi-Site Investigator-Initiated Clinical Trials of Natural Products (Collaborative UG3/UH3 Clinical Trial Required), applicants must meet the following criteria:

Details from the notice: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Applicant types on grants.gov (partial list): County governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; Small businesses; other applicants described in the notice; City or township governments; Public and State controlled institutions of higher education.

Eligibility requirements can change between funding cycles. Always verify the current criteria on the official Grants.gov listing before beginning your application.

How to apply: step by step

1. Register on SAM.gov. Every federal grant applicant needs an active SAM (System for Award Management) registration. Allow 2-4 weeks for new registrations to process. Existing registrations must be renewed annually.
2. Get a UEI number. Your Unique Entity Identifier is assigned through SAM.gov and replaces the old DUNS number. You will need this on every federal application.
3. Review the Notice of Funding Opportunity (NOFO). Download the full NOFO from the Grants.gov listing. Pay close attention to review criteria, budget limits, and required attachments.
4. Prepare your application package. Most federal grants require a project narrative, budget justification, organizational capacity statement, and supporting documents. Follow the page limits and formatting rules exactly.
5. Submit through Grants.gov. Create a workspace, upload all required forms and attachments, and submit once the next cycle opens. The system timestamps your submission, and late applications are automatically rejected.
6. Confirm receipt. Keep the tracking number or confirmation email, and check back in 1-2 business days that your application passed the validation checks.

For detailed guidance on writing a winning narrative, see our grant writing tips article.

Grant details

Federal grant budgets and priorities shift each fiscal year. The amounts listed above reflect the most recent funding cycle. For the latest figures, check the official program page.

If you are exploring business financing beyond grants, the team at CeoCult covers loans, lines of credit, and alternative funding for founders.

Frequently asked questions